To find out how well booster doses work, we compared data from ZOE COVID Study app contributors over the age of 55 who had received a booster with people in the same age group who hadn’t yet had their booster dose by 23rd November. Mix Match Vaccines How well do boosters work? In this latest analysis, 134,637 contributors got the same booster as their previous two vaccine doses, while 182,374 people got a ‘mix and match’ of various vaccine types.įor contributors who got three Pfizer doses, slightly fewer people reported systemic after effects after their booster (13.1%) compared to after their second dose (19.2%), and were also less likely to have local effects third time around.īy contrast, people getting ‘mix and match’ vaccines were 1.5 times more likely to have systemic after effects after their booster, particularly if they had a Moderna booster after two Pfizer or AstraZeneca vaccines. AstraZeneca is only being offered as a booster for people who are unable to have an mRNA vaccine for medical reasons. In the UK, most people are being offered either Pfizer or Moderna mRNA vaccine boosters, regardless of whether they had Pfizer, AstraZeneca or Moderna for their first two doses. Is it OK to ‘mix and match’ different COVID vaccines? The proportion of people experiencing local effects like tenderness and pain where they were injected was similar to what we found for the first two doses. The proportion of people experiencing whole body (systemic) effects after their booster is roughly the same (i.e low) compared to what we found for people having their first Pfizer doses (12.5%), compared with around one in three people having their first AstraZeneca vaccine (33%).
A much larger number of people - 232,596 (73.4%) - reported local effects like tenderness and pain around the site of injection. Overall, we found that 50,339 contributors (15.9%) reported having at least one whole body (systemic) effect, most commonly fatigue and headache. 27,761 received the Moderna vaccine as their booster, while 289,250 got a Pfizer jab. Together with our research colleagues at King’s College London, we looked at data from more than 317,000 ZOE COVID Study app contributors who logged at least one daily health report after their booster dose by the 23rd November 2021. It’s also common to experience local effects like pain, swelling, redness or itchiness at the site of the injection, or swelling of the glands (lymph nodes) in the armpit.
We’ve seen through studying the effects of the first two shots that this training response can feel a bit like the effects we get when we’re fighting off a real infection, including headaches fever, chills or shivers tiredness (fatigue) muscle or joint pains and diarrhea or feeling sick (nausea).
How does the booster vaccine make you feel?ĬOVID-19 vaccines work by using harmless parts of the SARS-CoV-2 coronavirus to train our immune system, so when we encounter the virus for real we’re able to fight it off. Here’s what we know so far about the after effects of booster jabs and what you can expect when you get yours. Millions of people have already received booster vaccines, with millions more to come over the next few weeks. Getting boosted now is the best way to protect yourself and those around you from COVID-19 through the winter. Is it OK to ‘mix and match’ different COVID vaccines?Ĭan you still catch COVID-19 after being boosted? How does the booster vaccine make you feel?ĭoes your booster vaccine dose feel worse?
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